I716F APP mutation associated with Alzheimer's and diffuse Lewy body disease

Evelyn Sieczkowski,Ivan Milenkovic,Regina Giera,Romana Hoftberger,Thomas Strobel,E Auff,Gabor G Kovacs

Journal of the Neurological Sciences（2013）

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摘要

Background: Neurodegenerative diseases (NDDs) are characterised by progressive loss of neurons and deposition of proteins in the brain. Mutations causing familial Alzheimer's disease (FAD) have been mainly described in three genes: amyloid precursor protein (APP), presenilin 1 (PSEN1) and presenilin 2 (PSEN2).

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i716f app mutation,alzheimer,disease

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