Genetic and structural analyses of cytochrome P450 hydroxylases in sex hormone biosynthesis: Sequential origin and subsequent coevolution

Jared V Goldstone,Munirathinam Sundaramoorthy,Bin Zhao,Michael R Waterman,John J Stegeman,David C Lamb

Molecular Phylogenetics and Evolution（2016）

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摘要

•Vertebrate steroid hormone synthesis pathways are 100s of millions of years old.•Relevant steroidogenic cytochrome P450s evolved sequentially in the deuterostomes.•CYP11-like genes preceded the appearance of CYP19 genes.•Substrate binding residues are highly conserved in each steroidogenic CYP family.

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关键词

Adx,CYP,HSD,PREG,DHEP,AND,PRG,TEST,POR

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