Angiopoietin-2 blocking antibodies reduce early atherosclerotic plaque development in mice

Thomas L Theelen,Jari P Lappalainen,Judith C Sluimer,Erika Gurzeler,J P Cleutjens,Marion J Gijbels,Erik A L Biessen,Mat J A P Daemen,Kari Alitalo,Seppo Ylaherttuala

Atherosclerosis（2015）

引用 47|浏览30

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摘要

•Antibody-mediated Ang-2 blockage delays fatty streak formation in mice.•Ang-2 blockage lowers plasma triglyceride levels.•Ang-2 blockage has no negative effects on preexisting atherosclerosis.

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关键词

Angiogenesis,Microvascular leakage,Plaque stability,Angiopoietin-2,Atherosclerosis

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