ChemInform Abstract: Highly Enantioselective Synthesis of α,α‐Dialkylmalonates by Phase‐Transfer Catalytic Desymmetrization.

The asymmetric phase-transfer catalytic α-alkylation of sterically hindered α-alkylmalonates (I) gives α,α-dialkylmalonates (III) with up to 99% yield and up to 97% e.e.