ChemInform Abstract: Effects of Nitrogen and Alkene Substitution on the PtCl2‐Catalyzed Cycloisomerization of N‐Tethered 1,6‐Enyne Precursors to the Triple Reuptake Inhibitor GSK1360707.

Vassil I Elitzin,Bing Liu,Matthew J Sharp,Elie Tabet

Cheminform（2011）

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摘要

The more electron-withdrawing the N-protecting group and the alkene substituent, the slower is the reaction rate of the cycloisomerization of 1,6-enynes to yield bicyclic products (II) and (IV).

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