ChemInform Abstract: Rapid Access to 1‐Benzyl 2‐Substituted Piperazines: Application to the Synthesis of 1‐Benzyl‐2‐difluoromethyl‐piperazine.

Abstract A rapid and efficient synthesis of 1-benzyl-2-difluoromethyl-piperazine is herein described. The new pathway has the advantage of avoiding orthogonal protection at the two piperazine nitrogen atoms; therefore it is suitable for access to several 1-benzyl 2-substituted piperazines starting from the simple commercially available N,N′-dibenzylethylendiamine.