ChemInform Abstract: Discovery of a Novel Series of Cyclic Urea as Potent CCR5 Antagonists.

Maosheng Duan,Wieslaw M Kazmierski,Matthew D Tallant,Jung Ho Jun,Mark Edelstein,Robert L Ferris, Dan Todd,Pat Wheelan,Zhiping Xiong

Cheminform（2012）

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摘要

Design and practical syntheses of a novel class of cyclic urea-based CCR5-antagonists demonstrating high antiviral activities against HIV-1 infection in both HOS and PBL assays are described.

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