Copper-catalyzed oxidative oxyalkylation of enol ethers with alpha-amino carbonyl compounds and hydroperoxides

A new copper-catalyzed oxidative difunctionalization of enol ethers with alpha-amino carbonyl compounds and hydroperoxides is developed. This method is experimentally simple while allowing for regioselective access to 2-amino-3,4-dioxy carbonyl compounds in good yields, and represents the first example of alkene oxyalkylation through C(sp(3))-H functionalization.