In situ antibiofilm effect of glass-ionomer cement containing dimethylaminododecyl methacrylate

•An in situ dental biofilm model was used to evaluate the novel glass ionomer cement (GIC) containing dimethylaminododecyl methacrylate (DMADDM).•DMADDM could increase surface charge density but reduce surface roughness.•The biofilm coverage and viability were significantly reduced on DMADDM containing samples compared to controls.