Synthesis and biological evaluation of 5,6,7-trimethoxy-1-benzylidene-3,4-dihydro-naphthalen-2-one as tubulin-polymerization inhibitors

Junhang Jiang,Canhui Zheng,Chongqing Wang,Juan Wang,Wei Tian,Chao Yang,Yunlong Song,Yong Hu,Ju Zhu,Youyun Zhou

Chinese Chemical Letters（2015）

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摘要

A series of new combretastatin-A4 analogs in which a six-membered ring connects the linking bridge and A ring were synthesized, and their tumor cell growth and tubulin-polymerization inhibitory activity were evaluated.

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关键词

Tubulin polymerization inhibitor,Antitumor agent,Combretastatin-A4 analog

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