Two new butanolides from the roots of Litsea acuminata

Hitoshi Tanaka,Yoshiaki Takaya, Junya Toyoda,Tadashi Yasuda,Masaru Sato,Jin Murata,Hiroko Murata, Koichi Kaburagi,Osamu Iida, Koji Sugimura,Eiji Sakai

Phytochemistry Letters（2015）

引用 18|浏览15

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摘要

•Two new butanolides (1 and 2) were isolated from the roots of Litsea acuminata (Lauraceae).•This is the first report of 4-hydroxy-5-methylbutanolides with a C10-side chain from a natural source.•The structures were determined by spectroscopic studies (IR, MS, 1D and 2D NMR) and chemical evidence.•Compounds 1–8 were evaluated for the cytotoxic activity against HeLa cell lines.

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关键词

Litsea acuminata,Lauraceae,Butanolides,Licunolide A,Licunolide B,Cytotoxicity

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