New Pregaliellalactonoids From Galiella Rufa

An extract of a culture of the fungus Galiella rufa yielded several new derivatives of pregaliellalactone (1) that were characterised by NMR and MS experiments. The tetraene 4 has been reported previously, but was in this investigation isolated in sufficient amounts for the determination of the configuration of the C-4/C-5 double bond which is Z, not E. The possibility that any of the new compounds are involved in the biosynthesis of 1 is discussed. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.