Evidence for TLR4 and FcRγ–CARD9 activation by cholera toxin B subunit and its direct bindings to TREM2 and LMIR5 receptors

Vongsavanh Phongsisay,Ei Ichi Iizasa,Hiromitsu Hara,Hiroki Yoshida

Molecular Immunology（2015）

引用 41|浏览11

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摘要

•Cholera toxin B subunit CTB possesses immunological properties.•CTB activates TLR4 and FcRγ–CARD9 signaling pathway.•CTB inhibits LMIR5 signaling triggered by 3-O-sulfo-β-d-galactosylceramide C24:1.•CTB induces signal transduction through DAP12-coupled TREM2.

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关键词

Cholera toxin,GM1,Receptor

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