AB1252 Subclinical left ventricular systolic dysfunction in patients with takayasu’s arteritis. A velocity vector imaging-based study

Background Takayasu’s arteritis (TA) is a chronic, granulomatous vasculitis of the aorta and its major branches. Impairment in left ventricular (LV) systolic function might be a major concern in TA due to chronic inflammation. Objectives We aimed to evaluate subclinical LV systolic dysfunction in patients with TA, without any cardiovascular disease and to compare them with patients with systemic lupus erythematosus (SLE), by using a novel strain imaging method, “velocity vector imaging” (VVI). Methods We studied 31 patients with TA (F/M, 29/2; mean age: 31,4), 18 patients with SLE (F/M, 17/1; mean age:32,3) and 20 20 age and sex-matched controls, without any cardiac disease and with preserved LV ejection fraction (EF). Conventional echocardiography and VVI- based strain imaging were performed to analyze subclinical LV systolic function. Results Conventional echocardiographic measurements (LV end diastolic diameter, LV end systolic diameter and LV EF) were similar between the groups. Longitudinal peak systolic strain (13.20±3.5% to 20.97±4.5%, p=0.0001) and strain rate (0.23±0.18 1/s to 4.92±0.55 1/s, p=0.0001) of the LV were significantly impaired in patients with TA, compared to controls, demonstrating subclinical ventricular systolic dysfunction. Supporting these results, we revealed impaired subclinical LV systolic function in patients with SLE, when compared to the control group (14±4.53% to 20.97±4.5%, p=0.0001 for strain; 0.23±0.12 1/s to 4.92±0.55 1/s, p=0.0001 for strain rate). The mean disease duration of the patient was 5.6 years in patients with TA. The LV systolic dysfunction was negatively correlated with disease duration, but this correlation couldn’t reach the statistical significance(r=-0,085, p=0,648.) Conclusions Ventricular long axis functions are important markers of myocardial contractility. Novel echocardiographic techniques may provide additional data for detecting early deterioration in ventricular systolic function in patients with systemic inflammatory diseases like TA and SLE. Disclosure of Interest None Declared