SAT0373 The role of the combination of bone and fall related risk factors on short-term subsequent fracture risk

Background Bone- and fall-related risk factors contribute to subsequent NVF risk and mortality Objectives We analysed whether a combination of bone-related and fall-related risk factors (RFs) in patients with a recent non-vertebral fracture (NVF) contributed to subsequent NVF risk and mortality during 2-years in patients who were offered after a mean of 3 months fall and fracture prevention according to their baseline risk and guidelines. Methods 834 consecutive patients aged ≥50 years with a recent NVF who were able and willing to participate were extensively evaluated for the presence of bone and fall RFs. We compared the yearly re-fracture risk and mortality in subgroups of patients according to the presence of bone RFs and/or fall RFs. Results Fifty seven patients (6.8%) had a subsequent NVF and 29 (3.5%) died within 2-years. During the first year the odds ratio for a subsequent fracture was 4.2 (95%CI:1.2-14.3) in patients with a combination of bone and fall RFs compared to patients with only bone RFs, and 2.8 (95%CI:1.4-5.8) compared to all patients without this combination. No differences in subsequent fracture risk were found in the second year. No significant differences in mortality were found between patients with or without bone and/or fall RFs. Conclusions Evaluation of fall RFs contributes to identifying patients with bone RFs at highest immediate risk of subsequent NVF. It should be further studied whether fall prevention immediately after a NVF can decrease fracture risk on top of anti-osteoporosis treatment in patients with a combination of bone and fall RFs. Disclosure of Interest None Declared