A CASE OF UNRESECTABLE PANCREAS CANCER TREATED WITH LOW DOSE CISPLATIN AND 5-FLUOROURACIL REGIMEN FOLLOWED BY A LONG SURVIVAL

This parer presents a case of pancretic cancer with liver and para-aortic lymph nodes involvement which was unresectable for prominent lymph nods metastasis and well responded to chemotherapy with low dose cisplatin and 5-fluorouracil. This patient was a 49-year-old man. After the unresectable operation, he was treated with chemotherapy of low dose cisplatin (CDDP) and 5-fluorouracil (5-FU) with low dose FP therapy which was given weelky by i. v. drip infusion at the first day. The combination of intravenous infusion of 5-FU (250mg/body) and CDDP (20mg/body) adminintered weekly. At 10 weeks, the serum CA19-9 and DUPANII level decreased within normal limits and the metastatic liver tumor and pancreatic cancer disappeared. The patient was discharged from the hospital and was given the low dose FP therapy biweekly on outpatient setting. Urticaria which is side effect of CDDP appeared after 38 courses of the low dose FP therapy, and thereafter only 5-FU (150mg/day oral) was given. After that, the tumor stopped to grow. The patient has been doing well as of 5 years after the admission. The lom dose FP therapy for patients with unresectable pancreatic cancer is recommended for selected cases.