Metabolomics and transcriptomics identify pathway differences between visceral and subcutaneous adipose tissue in colorectal cancer patients: the ColoCare study

Liesenfeld David B,Grapov Dmitry,Fahrmann Johannes F, Salou Mariam,Scherer Dominique,Toth Reka,Habermann Nina,Böhm Jürgen,Schrotz-King Petra,Gigic Biljana,Schneider Martin,Ulrich Alexis,Herpel Esther,Schirmacher Peter,Fiehn Oliver,Lampe Johanna W,Ulrich Cornelia M

AMERICAN JOURNAL OF CLINICAL NUTRITION（2015）

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摘要

Background: Metabolic and transcriptomic differences between visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) compartments, particularly in the context of obesity, may play a role in colorectal carcinogenesis. We investigated the differential functions of their metabolic compositions.

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colorectal cancer,obesity,adipose tissue,visceral adiposity,metabolomics,inflammation

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