Copper improves the anti-angiogenic activity of disulfiram through the EGFR/Src/VEGF pathway in gliomas

Yi Li,Shi-Yuan Fu,Li-Hui Wang,Fang-Yang Wang,Nan-Nan Wang,Qi Cao,Ya-Ting Wang,Jing-Yu Yang,Chun-Fu Wu

Cancer Letters（2015）

引用 66|浏览8

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摘要

•DSF potently inhibited angiogenesis both in vitro and in vivo.•Cu improves the anti-angiogenic ability of DSF both in vitro and in vivo.•DSF/Cu suppresses VEGF secretion through EGFR/c-Src/VEGF pathway.

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关键词

Disulfiram,Copper,Angiogenesis,VEGF

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