Fulminant neurologic manifestation of Systemic Lupus Erythematosus
Archive of Clinical Cases(2014)
摘要
Central nervous system (CNS) presentations of Systemic Lupus Erythematosus (SLE) may be focal neurological and diffuse psychiatric manifestations. We are reporting a clinical case of severe neurologic manifestations on a 19 year old woman with SLE diagnosed in the Neurology clinic. Severe neurological involvement in SLE is one of the most dreadful complications of the disease, associated with a poor prognosis. The problem remains what is the molecular support of such an important cerebral event. Blood brain barrier endothelium is apparently a target for several pathogenic mechanisms that can account for the CNS manifestations of SLE. The autoimmune response in SLE might affect endothelial cells through several mechanisms and different mediators: endothelial activation/damage may be mediated by C1q.
更多查看译文
关键词
central nervous system
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要