Pediatric Herpes Simplex Virus Encephalitis Complicated By N-Methyl-D-Aspartate Receptor Antibody Encephalitis

Alasdair Bamford, Belinda H. A. Crowe,Yael Hacohen,Jean-Pierre Lin,Antonia Clarke, Gareth Tudor-Williams,Vanessa Sancho-Shimizu,Angela Vincent,Ming Lim,Sunil P. Pullaperuma

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY（2015）

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摘要

N-methyl-D-aspartate receptor antibodies (NMDAR-Abs) can contribute to neurological relapse after herpes simplex virus encephalitis (HSE). We describe a child with NMDAR-Ab encephalitis after HSE, which was recognized and treated early. We discuss the case in the context of existing reports, and we propose a modified immunotherapy strategy to minimize risk of viral reactivation.

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关键词

encephalitis,HSV,NMDAR,pediatric,plasmapheresis

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