CRF19_cpx is an Evolutionary fit HIV-1 Variant Strongly Associated With Rapid Progression to AIDS in Cuba

Vivian Kouri,Ricardo Khouri,Yoan Aleman,Yeissel Abrahantes,Jurgen Vercauteren,Andreaclemencia Pinedapena,Kristof Theys,Sarah Megens,Michel Moutschen,Nico Pfeifer,Johan Van Weyenbergh,A Perez,Jorge Perez,Lissette Perez,Kristel Van Laethem,Annemieke Vandamme

EBioMedicine（2015）

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摘要

•We propose that CRF19 is evolutionary very fit, causing rapid progression to AIDS in many newly infected patients in Cuba.•CRF19 is a recombinant of subtype D, subtype A and subtype G, with a subtype D protease estimated to be particularly fit.•A fit protease with high viral load and co-infections, may boost RANTES levels and thus CXCR4 use, hence fast progression.

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关键词

CRF19,HIV-1,Variant,Progression to AIDS,Cuba

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