Myc — Proteinstabilität als Angriffsziel für zielgerichtete Therapien

The Myc transcription factor family affects the expression of a large group of genes that play an important role during tumourigenesis. Therefore, deregulated expression of the MYC gene family is a hallmark of multiple human tumours. An indirect reduction of Myc-protein levels due to interference with protein-stabilizing mechanisms could be a promising therapeutic approach targeting Myc-dependent tumours.