Activation of Latent Human Immunodeficiency Virus by the Histone Deacetylase Inhibitor Panobinostat: A Pilot Study to Assess Effects on the Central Nervous System

    Open forum infectious diseases, Volume 2, Issue 1, 2015.

    Cited by: 3|Bibtex|Views0|Links
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    Keywords:
    central nervous systemcerebrospinal fluidhistone deacetylase inhibitorshuman immunodeficiency viruspanobinostat

    Abstract:

    In a substudy of a clinical trial, we assessed whether activation of latent human immunodeficiency virus (HIV) by the histone deacetylase inhibitor panobinostat had detrimental effects on the central nervous system (CNS). Adults infected with HIV received oral panobinostat 20 mg 3 times per week every other week for 8 weeks. In cerebrospi...More

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