Tumor Necrosis Factor-Alpha and Mast Cells: Revisited Study

A Saggini,D Tripodi,G Maccauro,M L Castellani,A Anogeianaki,S Tete,P Felaco,M A De Lutiis,R Galzio,M Fulcheri,Theoharis C Theoharides,A Caraffa,P Antinolfi,Mario Felaco,F Conti,Giovanni Neri,Franco Pandolfi, E Toniato,Y B Shaik Dasthagirisaheb

EUROPEAN JOURNAL OF INFLAMMATION（2011）

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摘要

Mast cells reside in connective tissues and are widely recognized as effector cells important in innate and acquired immunity. These cells are the only ones capable of storing preformed TNF alpha in their cytoplasmatic granules and release upon activation. TNF-alpha is a potent multifunctional cytokine involved in autoimmune diseases, cancer, allergy, and acute and chronic inflammation, in this study, we revisit the interrelationship between TNF alpha and mast cells.

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关键词

mast cells,tumor necrosis factor-alpha,cytokines,inflammation

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