Progress In The Development Of A Tomographic SPECT System For Online Dosimetry In BNCT
AIP Conference Proceedings(2010)
摘要
In boron neutron capture therapy (BNCT) the delivered dose to the patient depends both on the neutron beam characteristics and on the B-10 body distribution which, in turn, is governed by the tumor specificity of B-10 drug-carrier. BNCT dosimetry is a complex matter due to the several interactions that neutrons can undergo with the different nuclei present in tissue. However the boron capture reaction B-10(n,alpha)Li-7 accounts for about 80 % of the total dose in a tumor with 40 ppm in B-10 concentration. Present dosimetric methods are indirect, based on drug biodistribution statistical data and subjected to inter and intra-patient variability. In order to overcome the consequences of the concomitant high dosimetric uncertainties, we propose a SPECT (Single Photon Emission Tomography) approach based on the detection of the prompt gamma-ray (478 keV) emitted in 94 % of the cases from Li-7. For this purpose we designed, built and tested a prototype based on LaBr3(Ce) scintillators. Measurements on a head and tumor phantom were performed in the accelerator-based BNCT facility of the University of Birmingham (UK). They result in the first tomographic image of the B-10 capture distribution obtained in a BNCT facility.
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关键词
BNCT,Dosymetry,SPECT
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