Antihypertensive Activity, Cardiac Performance and Pharmacokinetics of Bunazosin, a Novel α1-Adrenoceptor Antagonist, in Patients with Normal and Impaired Renal Function

Axel Mescheder,Atef Halabi,A Nokhodian,Yousif Alhamdan,Wilhelm Kirch

Drug Investigation（2012）

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摘要

In order to investigate the possible impact of chronic renal insufficiency on the pharmacokinetic and pharmacodynamic properties of bunazosin, 3mg of this novel α 1-adrenoceptor antagonist were administered once daily for 2 weeks to 24 patients with hypertension. 12 of the patients had normal renal function (controls) while 12 others suffered from chronic renal insufficiency.

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关键词

Cardiac Output, Stroke Volume, Prazosin, Normal Renal Function, Impaired Renal Function

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