PS5 - 30. Deciphering glycosphingolipid metabolism in sorted adipose tissue macrophages from lean and obese mice.

Tanit L. Gabriel,Roelof Ottenhof,Cindy van Roomen,Berend Hooibrink, Johanes M.F.G. Aerts,Marco van Eijk

Nederlands Tijdschrift voor Diabetologie（2015）

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摘要

Glycosphingolipids (GSL) essentially contribute to the development of insulin resistance (IR) in adipose tissue. On one hand GSL such as the ganglioside GM3 have been shown to cause insulin resistance (IR) in adipocytes, on the other hand macrophages have to buffer adipose lipid spillage causing a foamy cell appearance.

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关键词

Insulin Resistance,Adipose Tissue,White Adipose Tissue,Obese Mouse,Stromal Vascular Fraction

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