Ataxin-10 is part of a cachexokine cocktail triggering cardiac metabolic dysfunction in cancer cachexia

Molecular Metabolism（2016）

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摘要

•Cancer cachexia induces remodeling of the heart.•Tumor-borne secreted factors mediate cardiomyocyte atrophy.•Selective cachexokines, including Bin1, Stx7, Minpp1, Gaa, Ccl2, Adamtsl4, and Atxn10 provoke aberrant cardiac FA metabolism.•Ataxin-10 levels are elevated under cachectic conditions in mice and tumor patients.

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关键词

Cancer cachexia,Ataxin-10,Cardiac dysfunction,Fatty acid metabolism

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