HIV-1 genotypic drug resistance testing: digging deep, reaching wide?
Current Opinion in Virology(2015)
摘要
•Technological innovations enable the global roll-out of drug resistance surveillance.•Next-generation sequencing provides an answer for simultaneous resistance monitoring against all drugs.•Drug-class specific minority variants are associated with an increased risk of virological failure.•As a prognostic tool, ultra-deep sequencing has not yet shown to be superior over Sanger sequencing.•Technological innovations support scientific advancements that could improve prognostic testing.
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