Investigation of HP-beta-CD Inclusion Compound Preparation Process for Pulsatilla Chinensis (Bunge) Regel Total Saponins1

This paper used parallel test of single factor to investigate feed ratio of inclusion compound, drying method, the volatilization temperature of ethanol for Pulsatilla Chinensis (Bunge) Regel total saponins-HP-beta-CD inclusion compound. The results showed that the best preparation process of inclusion compound was as following: the feed ratio of Pulsatilla total saponin extract and HP-beta-CD was 1: 1; After the Pulsatilla total saponins extract with ethanol solution was dropwise added to the HP-beta-CD aqueous solution, the mixed solution was continuously stirred for 6h at 60C and was freeze-dried for 12h. The preparation process for Pulsatilla Chinensis (Bunge) Regel total saponins-HP-beta-CD inclusion compound was simple and it is helpful to improve the drug dissolution.