The Relationship Between Glycemic Control And Asymmetrical Dimethylarginine Levels

Objective: The relationship of asymmetrical dimethylarginine (ADMA) and glycemic control in diabetes is not yet fully enlightened. We aim to investigate the association of ADMA and hemoglobin A1c (HbA1c) in normal glomerular filtration rate (GFR) diabetic patients. Methods: This cross sectional study included 88 diabetic patients whose GFRs were in reference range. 2 different HbA1c values; current (cHbA1c) and mean of 4 successive measurements with 3 months intervals (mHbA1c) were used. The association of ADMA with HbA1c levels and other clinical characteristics of patients were evaluated. Results: We found significant inverse correlations between ADMA and both current (r=-0,354, p=0,001) and mean HbA1c(r=-0,377, p=0,000) levels. In multiple lineer regression analyses mHbA1c, glucose and duration of diabetes (R-2 = 0,343, p=0,000) or cHbA1c, glucose and duration of diabetes (R-2 = 0,318 p<0,001) were predictive variables for ADMA concentrations. Conclusion: The study indicated that, long term poor glycemic control is associated with decreased ADMA levels.