IL-13 improves beta-cell survival and protects against IL-1beta-induced beta-cell death

Sabine Rutti,Cedric Howald,Caroline Arous,Emmanouil T Dermitzakis,Philippe A Halban,Karim Bouzakri

Molecular Metabolism（2016）

引用 21|浏览29

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摘要

•IL-13 decreases human beta-cells apoptosis.•IL-13 protects primary beta-cells form cytokine induced apoptosis.•The IRS2/akt pathway mediates IL-13 protective effects.•IL-13 modulates the expression of genes involved in stress response.

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关键词

Beta-cells,Apoptosis,Cytokines,Gene expression,Akt

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