Mechanism by Which Inflammation and Oxidative Stress Induce Mineralocorticoid Receptor Gene Expression in Aging Vascular Smooth Muscle Cells.
Hypertension (Dallas, Tex. : 1979)(2023)
摘要
These data implicate the inflammatory TF, NFκB, and oxidative stress-induced TF, HIF1α, in regulating SMC MR transcription in aging HASMCs, which drives aging-related vascular stiffness and cardiovascular disease.
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关键词
NF-kappa B,aging,genes, regulator,myocytes, smooth muscle,oxidative stress,receptors, mineralocorticoid
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