Scaling probabilistic models of genetic variation to millions of humans

Nature Genetics, 2014, Pages 1-32.

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Keywords:
Population geneticsComputational biology and bioinformatics

Abstract:

A major goal of population genetics is to quantitatively understand variation of genetic polymorphisms among individuals. The aggregated number of genotyped humans is currently on the order of millions of individuals, and existing methods do not scale to data of this size. To solve this problem, we developed TeraStructure, an algorithm to...More

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