Breast density measurement: 3D cone beam computed tomography (CBCT) images versus 2D digital mammograms
Proceedings of SPIE(2009)
摘要
Breast density has been recognized as one of the major risk factors for breast cancer. However, breast
density is currently estimated using mammograms which are intrinsically 2D in nature and cannot
accurately represent the real breast anatomy. In this study, a novel technique for measuring breast density
based on the segmentation of 3D cone beam CT (CBCT) images was developed and the results were
compared to those obtained from 2D digital mammograms. 16 mastectomy breast specimens were imaged
with a bench top flat-panel based CBCT system. The reconstructed 3D CT images were corrected for the
cupping artifacts and then filtered to reduce the noise level, followed by using threshold-based
segmentation to separate the dense tissue from the adipose tissue. For each breast specimen, volumes of the
dense tissue structures and the entire breast were computed and used to calculate the volumetric breast
density. BI-RADS categories were derived from the measured breast densities and compared with those
estimated from conventional digital mammograms. The results show that in 10 of 16 cases the BI-RADS
categories derived from the CBCT images were lower than those derived from the mammograms by one
category. Thus, breasts considered as dense in mammographic examinations may not be considered as
dense with the CBCT images. This result indicates that the relation between breast cancer risk and true
(volumetric) breast density needs to be further investigated.
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关键词
adipose tissue,risk factors,electronic test equipment,computed tomography,breast cancer
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