Role Of Mast Cells And Angiogenesis In Different Histological Types Of Ameloblastoma

Objective: To study the role of mast cells and angiogenesis in different histological types of ameloblastoma.Methodology: In this prospective study, 28 biopsies of different histological types of ameloblastoma were evaluated. Microvessels were stained with CD-34 and mast cells were counted using Toluidine blue stain.Results: Mean age of patients was 29.71 +/- 2.544 (95% Cl: 24.4934.93). The most common histological type was plexiform followed by follicular type. Mandible was more commonly involved (89.3%) than maxilla (10.7%). Mean mast cell count in all 28 cases was 6.39 +/- 0.915 and was significantly higher than normal oral mucosa (p=0.000). Mean microvessel count was 12.75 +/- 1.234 but it was not significantly higher than mean MVD of normal oral mucosa (p=0.242). The mast cell count differed significantly among different histological types of ameloblastomaConclusion: The mast cell density was significantly increased in ameloblastoma but the increase in mast cells did not correlate with angiogenesis in and around the tumour tissue.