Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase IV by promoting the binding of Mg2 + to the second metal binding site

Lisa M Oppegard,Heidi A Schwanz,Tyrell Towle,Robert J Kerns,Hiroshi Hiasa

Biochimica et Biophysica Acta (BBA) - General Subjects（2016）

引用 8|浏览7

暂无评分

摘要

•Fluoroquinolones promote the binding of Mg2+ to site B to stimulate strand breakage.•Fluoroquinolones may inhibit religation by stabilizing Mg2+ binding at site B.•Quinazolinediones act by the same mechanisms as fluoroquinolones.•Topoisomerase IV cannot complete the catalytic reaction using Ca2+ as a cofactor.

查看译文

关键词

Divalent metal ion,DNA gyrase,Fluoroquinolone,Quinazolinedione,Topoisomerase IV

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要