ImmTACs: bi-specific TCR-anti-CD3 fusions for targeted tumour killing

Zoe Donnellan,Giovanna Bossi,Jane Harper,Joseph Dukes,Nathaniel Liddy,Samantha Paston,Tara Mahon, Peter Molloy,Malkit Sami,Emma Baston,Brian Cameron,Andrew Johnson,Annelise Vuidepot,Namir Hassan,Bent Jakobsen

Journal for ImmunoTherapy of Cancer（2015）

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摘要

Meeting abstracts Tumour-specific T cells have the potential to eradicate cancer. However anti-tumour immunity is limited by low TCR affinities, MHC downregulation by cancer cells and an immunosuppressive tumour microenvironment. As most tumour-associated antigens are auto-antigens, tumour specific

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关键词

Melanoma Cell, Tumour Killing, Immunosuppressive Tumour Microenvironment, Stage Cancer Patient, Patient Peripheral Blood

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