CYP2C19 Phenoconversion in patients with Breast Cancer and alterations in Bioactivation of Cyclophosphamide

August 2015 e41 Conclusion: Target exposure post IAM was similar to systemic full dose administration but with minimal systemic effects. Our findings are being validated in larger studies in animals and humans using different targets and classes of drugs. IAM could enable safe, inexpensive and early study of novel drugs at the first-in-man stage and the study of established drugs in vulnerable populations.