Moving Ahead On Harnessing Synthetic Lethality To Fight Cancer
MOLECULAR & CELLULAR ONCOLOGY(2015)
摘要
We have recently developed a data-mining pipeline that comprehensively identifies cancer unique susceptibilities, following the concept of Synthetic Lethality (SL). The approach enables, for the first time, to identify and harness genome-scale SL-networks to accurately predict gene essentiality, drug response, and clinical prognosis in cancer.
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关键词
synthetic lethality, genetic interactions, cancer genomics, precision medicine
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