Usage Of Enzymes In The Therapy Of Chronic Wounds. Preliminary Results

We present our preliminary results of clinical application of two original enzyme-derived topical preparations, Neprolysin and Post-Neprol, on patients with chronic wounds. Neprolysin is a preparation containing a purified proteolytic enzyme possessing strong activity in the neutral pH-area. The main active component of Post-Neprol is collagen hydrolysate. The aim of the study is to assess the safety and efficacy of local enzymatic treatment of chronic wounds. For a period of 3 years, in a single institution 56 patients suffering from chronic wounds were treated. Twenty-two % of the patients were discharged with fully epithelized healed wounds. The rest (78%) of the patients were discharged with continuously healing non-infected wounds. It was found that the application of Neprolysin and Post-Neprol in complex treatment of patients with chronic wounds is safe and promises effectiveness. Control randomized clinical trials were warranted.