The effects of chronic doses of tricyanoaminopropene on water consumption in the rat

Twenty albino rats of the Wistar strain were assigned to one of four groups (7, 14, or 28 mg/kg TRIAP) or a control group receiving 3% tragacanth. All Ss were given chronic injections of the appropriate drug for a 35-day period. The amount of water consumed was measured over a 3-day period, and it was found that no differences existed between the groups. A dose-related tolerance mechanism was discussed.