Divide And Rule: The Role Of Ubiquitination In Inactivation Of The Erk5-Mapk Cascade
MOLECULAR & CELLULAR ONCOLOGY(2014)
摘要
Recently, we revealed that ubiquitination of MEKK2 and MEKK3 by inhibitor of apoptosis proteins (IAPs) directly disrupts MEK5/ERK5 interaction and subsequently attenuates ERK5 activation. In addition, loss of XIAP promotes human myogenic differentiation in an ERK5-dependent manner. These results reveal another layer of MAPK regulation and a novel role for XIAP in controlling myogenic differentiation.
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关键词
cIAP1,ERK5,IAP,MAPK,PB1,ubiquitin,XIAP
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