Disintegration and Esophageal Irritation Profiles of Alendronate Formulations:Implications for Clinical Safety and Efficacy

Merck Frosst,Solomon Epstein,Piet Geusens,John E. Fisher,Susan L. Hill, Sophie Roy,Gideon Rodan,Nagaraja Muniappa,Gordon K. Wo,Laurence Handt, Nancy Kelly,Chi-Chung Chan,Alfred A. Reszka,Srinivasa Prahalada

msra（2005）

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摘要

Background:Fosamax (alendronate sodium,Merck & Co.,Inc.,Whitehouse Station,NJ,USA) is an effective oral bisphosphonate widely used to treat and prevent osteoporosis,with a safety and tolerability profile similar to placebo in clinical trials.It has been evaluated in clinical trials with over 20,000 partici- pants and up to 10 years duration.Oral

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