FcgRIIIA (CD16)-expressing monocytes mediate the depletion of tumor-infiltrating Tregs via Ipilimumab-dependent ADCC in melanoma patients

Emanuela Romano, Monika Kusio-Kobialka,Periklis G Foukas,Helene Bichat,Petra Baumgaertner,Christiane Meyer,Pierluigi Ballabeni,Olivier Michielin,Benjamin Weide,Pedro Romero,Daniel E Speiser

Journal for ImmunoTherapy of Cancer（2014）

引用 4|浏览17

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摘要

Meeting abstracts Enhancing immune responses with immune-modulatory monoclonal antibodies (mAbs) directed to inhibitory immune-receptors is a promising modality in cancer therapy. Clinical efficacy has been demonstrated with antibodies blocking inhibitory immune checkpoints such as CTLA-4 or PD-1/

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关键词

Melanoma, Melanoma Patient, Ipilimumab, Immune Checkpoint, Inhibitory Immune Checkpoint

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