Conformational Exchange Processes in Biological Systems: Detection by Solid‐State NMR

We review recent advances in methodologies to study microseconds-to-milliseconds exchange processes in biological molecules using magic-angle spinning solid-state nuclear magnetic resonance (MAS ssNMR) spectroscopy. The particularities of MAS ssNMR, as compared to solution-state NMR, are elucidated using numerical simulations and experimental data. These simulations reveal the potential of MAS NMR to provide detailed insight into short-lived conformations of biological molecules. Recent studies of conformational exchange dynamics in microcrystalline ubiquitin are discussed.