INTERSTITIAL PHOTODYNAMIC THERAPY (PDT) OF SOLID TUMOR

Photodynamic therapy (PDT) involves the administration of photosensitizer followed by local illumination with visible light of specific wavelength(s). In the presence of Oxygen molecules. the light illumination Of photosensitizer can lead to a series of photochemical reactions and consequently the generation of cytotoxic species, The (quantity and location of PDT-induced cytotoxic species determine the nature and consequence of PDT. Much progress has been seen in both basic research and clinical application in recent years. Although the majority of approved PDT clinical protocols have primarily been used for the treatment Of superficial lesions of both malignant and non-malignant diseases. interstitial PDT approaches for the ablation of deep-seated solid tumors are now being investigated worldwide. The complexity of geometry and inhomogeneity Of Solid tumor pose a great technical challenge on the implementation of minimally invasive interstitial PDT. This presentation will discuss the recent progress and challenges of various forms of interstitial PDT.