Comparative proteomic analysis of growth hormone secretagogue A233 treatment of murine macrophage cells J774A.2 indicates it has a role in antiviral innate response. ☆

Rebeca Martinez,Teresa Nunez De Villavicenciodiaz,Aniel Sanchez Puente,Yassel Ramos, Jesus Noda Ferro, M E Mendez,Elsa Rodriguez,Ernesto Marcos, Belinda Sanchez,Yordanka Maforrol,Hilda Garay,Fernando Albericio,Lisset Hermida,Luis Javier Gonzalez,Eva Vonasek,Mario P Estrada,Vladimir Besada

Biochemistry and Biophysics Reports（2016）

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摘要

•Peptide treatment increases superoxide anion production in J774 macrophage cells.•A233 peptide treatment increases INF-γ levels in mouse splenocytes.•Mice treated with A233 significantly reduce viral load after challenge with DENV-3.•Peptide treatment may activates cytotoxic functions and exert an antiviral effect.

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关键词

DENV,GHRP-6,[d-Lys3]-GHRP-6t,GHS,IFN-γ,LPS,O2•−,RNS,ROS

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