PS15 - 72. In vivo targeting of glycosphingolipid catabolism: will it work for obesity/type 2 diabetes?

Wouter W. Kallemeijn,Tanit L. Gabriel,Maria J. Ferraz,Roelof Ottenhoff,Cindy P. A. A. van Roomen,Hermen S. Overkleeft,Johannes M. F. G. Aerts,Marco van Eijk

Nederlands Tijdschrift voor Diabetologie（2015）

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摘要

Glycosphingolipids (GSL) are implicated to play an important role in insulin resistance. We have recently described (using several rodent models of type 2 diabetes) that lowering of GSL synthesis by pharmacological inhibition of glucosylceramide synthase with the iminosugar AMPDNM, improves insulin sensitivity in adipocytes, liver and muscle.

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关键词

Adipose Tissue,Ceramide,Pharmacological Inhibition,Gauche Disease,Improve Insulin Sensitivity

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