Synthesis of new isoxazole derivatives with larvicidal activity

One of the major routes of detoxification (removal of free radicals) in Aedes aegypti mosquitos is the kynurenine pathway. In this biochemical pathway, the most important reaction is the conversion of 3-hydroxykynurenine (3-HK), a harmful metabolite that leads to insect death, into xanthurenic acid, a nontoxic substance. This conversion is performed by the enzyme 3-hydroxy-kynurenine transaminase (HKT). 1